Photo of Dr Subhabrata Mitra

Dr Subhabrata Mitra

Telephone:

Location:

  • Elizabeth Garrett Anderson Wing

GMC/GDC number:

6031801

Professional background

Dr Subhabrata Mitra is a consultant in neonatal medicine working within the Elizabeth Garrett Anderson Wing at UCLH. He studied medicine in University of Calcutta, India and completed his postgraduation in paediatrics there. He subsequently completed further paediatric and neonatal training in Bristol, Cambridge and UCLH. He has an interest in perinatal brain injury and subsequent neurodevelopmental outcome.

He completed a PhD at University College London in the Institute for Women’s Health investigating the role of broadband near infrared spectroscopy measured cytochrome c oxidase in neonatal encephalopathy and neonatal seizures. He is now leading the clinical neurosciences research programme in UCLH and supported by a Welcome Trust Fellowship.

He works closely with a team of engineers, physicists and basic scientists. His aim is to develop early biomarkers of outcome following perinatal brain injury using advanced neuromonitoring and neuroimaging technologies, and identification of seizure induced changes in neonatal brain in real time to improve seizure detection tools and management strategy.

Specialties

Research interests

Perinatal brain injury, neonatal seizures, neonatal encephalopathy, neonatal neuromonitoring and neuroimaging, neurodevelopmental outcome

Languages spoken

Bengali

Publications

  • Vezyroglou, A.; Hebden, P.; De Roever, I.; Thornton, R.; Mitra, S.; Worley, A.; Alves, M.; Dean, E.; Cross, J.H.; Tachtsidis, I. Broadband-NIRS System Identifies Epileptic Focus in a Child with Focal Cortical Dysplasia—A Case Study. Metabolites 2022, 12, 260.
  • Tachtsidis I, Lange F, Pinti P, Bale G, Sokolska M, Avdic-Belltheus A, Meehan C, Robertson N, Parsa S, Weigel U, Dududran T, Mitra S (2021). An optical biomarker of hypoxic-ischaemic injury severity in the neonatal brain. Proc. SPIE Vol. 11920 Diffuse Optical Spectroscopy and Imaging VIII, 119200I.
  • Koskela T, Kendall GS, Memon S, Sokolska M, Mabuza T, Huertas-Ceballos A, Mitra S, Robertson NJ, Meek J, Whitehead K. Prognostic value of neonatal EEG following therapeutic hypothermia in survivors of hypoxic-ischemic encephalopathy. Clin Neurophysiol. 2021 Sep;132(9):2091-2100.
  • Russell-Buckland J, Kaynezhad P, Mitra S, Bale G, Bauer C, Lingam I, Meehan C, Avdic-Belltheus A, Martinello K, Bainbridge A, Robertson NJ, Tachtsidis I. Systems Biology Model of Cerebral Oxygen Delivery and Metabolism During Therapeutic Hypothermia: Application to the Piglet Model. Adv Exp Med Biol. 2021;1269:31-38.
  • Harvey-Jones K, Lange F, Tachtsidis I, Robertson NJ, Mitra S. Role of Optical Neuromonitoring in Neonatal Encephalopathy-Current State and Recent Advances. Front Pediatr. 2021 Apr 9;9:653676.
  • Kovacsova Z, Bale G, Mitra S, Lange F, Tachtsidis I. Absolute quantification of cerebral tissue oxygen saturation with multidistance broadband NIRS in newborn brain. Biomed Opt Express. 2021 Jan 15;12(2):907-925.
  • Pavel AM, Rennie JM, de Vries LS, Blennow M, Foran A, Shah DK, Pressler RM, Kapellou O, Dempsey EM, Mathieson SR, Pavlidis E, van Huffelen AC, Livingstone V, Toet MC, Weeke LC, Finder M, Mitra S, Murray DM, Marnane WP, Boylan GB. A machine-learning algorithm for neonatal seizure recognition: a multicentre, randomised, controlled trial. Lancet Child Adolesc Health. 2020 Oct;4(10):740-749.
  • Bale G, Mitra S, Tachtsidis I. Metabolic brain measurements in the newborn: Advances in optical technologies. Physiol Rep. 2020 Sep;8(17):e14548.
  • Pang R, Mintoft A, Crowley R, Sellwood M, Mitra S, Robertson NJ. Optimizing hemodynamic care in neonatal encephalopathy. Semin Fetal Neonatal Med. 2020 Oct;25(5):101139.
  • Mitra S, Bale G, Meek J, Tachtsidis I, Robertson NJ. Cerebral Near Infrared Spectroscopy Monitoring in Term Infants With Hypoxic Ischemic Encephalopathy-A Systematic Review. Front Neurol. 2020 May 27;11:393.
  • Bale G, Taylor N, Mitra S, Sudakou A, de Roever I, Meek J, Robertson N, Tachtsidis I. Near-Infrared Spectroscopy Measured Cerebral Blood Flow from Spontaneous Oxygenation Changes in Neonatal Brain Injury. Adv Exp Med Biol. 2020;1232:3-9.
  • Mitra S, Bale G, de Roever I, Meek J, Robertson NJ, Tachtsidis I. Changes in Brain Tissue Oxygenation and Metabolism During Rewarming After Neonatal Encephalopathy are Related to Electrical Abnormality. Adv Exp Med Biol. 2020;1232:25-31.
  • Kaynezhad P, Mitra S, Bale G, Bauer C, Lingam I, Meehan C, Avdic-Belltheus A, Martinello KA, Bainbridge A, Robertson NJ, Tachtsidis I. Quantification of the severity of hypoxic-ischemic brain injury in a neonatal preclinical model using measurements of cytochrome-c-oxidase from a miniature broadband-near-infrared spectroscopy system. Neurophotonics. 2019 Oct;6(4):045009.
  • Mitra S, Bale G, Highton D, Gunny R, Uria-Avellanal C, Bainbridge A, Sokolska M, Price D, Huertas-Ceballos A, Kendall GS, Meek J, Tachtsidis I, Robertson NJ. Pressure passivity of cerebral mitochondrial metabolism is associated with poor outcome following perinatal hypoxic ischemic brain injury. J Cereb Blood Flow Metab. 2019 Jan;39(1):118-130.
  • Mitra S, Kendall GS, Bainbridge A, Sokolska M, Dinan M, Uria-Avellanal C, Price D, Mckinnon K, Gunny R, Huertas-Ceballos A, Golay X, Robertson NJ. Proton magnetic resonance spectroscopy lactate/N-acetylaspartate within 2 weeks of birth accurately predicts 2-year motor, cognitive and language outcomes in neonatal encephalopathy after therapeutic hypothermia. Arch Dis Child Fetal Neonatal Ed. 2019 Jul;104(4):F424-F432.
  • de Roever I, Bale G, Mitra S, Meek J, Robertson NJ, Tachtsidis I. Investigation of the Pattern of the Hemodynamic Response as Measured by Functional Near-Infrared Spectroscopy (fNIRS) Studies in Newborns, Less Than a Month Old: A Systematic Review. Front Hum Neurosci. 2018 Oct 2;12:371.
  • Kovacsova Z, Bale G, Mitra S, de Roever I, Meek J, Robertson N, Tachtsidis I. Investigation of Confounding Factors in Measuring Tissue Saturation with NIRS Spatially Resolved Spectroscopy. Adv Exp Med Biol. 2018;1072:307-312.
  • Bale G, Mitra S, de Roever I, Sokolska M, Price D, Bainbridge A, Gunny R, Uria-Avellanal C, Kendall GS, Meek J, Robertson NJ, Tachtsidis I. Oxygen dependency of mitochondrial metabolism indicates outcome of newborn brain injury. J Cereb Blood Flow Metab. 2019 Oct;39(10):2035-2047.
  • Mitra S, Rennie J. Neonatal jaundice: aetiology, diagnosis and treatment. Br J Hosp Med (Lond). 2017 Dec 2;78(12):699-704.
  • Holper L, Mitra S, Bale G, Robertson N, Tachtsidis I. Prediction of brain tissue temperature using near-infrared spectroscopy. Neurophotonics. 2017 Apr;4(2):021106.
  • Martinello K, Hart AR, Yap S, Mitra S, Robertson NJ. Management and investigation of neonatal encephalopathy: 2017 update. Arch Dis Child Fetal Neonatal Ed. 2017 Jul;102(4):F346-F358.
  • Proisy M, Mitra S, Uria-Avellana C, Sokolska M, Robertson NJ, Le Jeune F, Ferré JC. Brain Perfusion Imaging in Neonates: An Overview. AJNR Am J Neuroradiol. 2016 Oct;37(10):1766-1773.
  • Mitra S, Bale G, Meek J, Uria-Avellanal C, Robertson NJ, Tachtsidis I. Relationship Between Cerebral Oxygenation and Metabolism During Rewarming in Newborn Infants After Therapeutic Hypothermia Following Hypoxic-Ischemic Brain Injury. Adv Exp Med Biol. 2016;923:245-251.
  • Bale G, Mitra S, de Roever I, Chan M, Caicedo-Dorado A, Meek J, Robertson N, Tachtsidis I. Interrelationship Between Broadband NIRS Measurements of Cerebral Cytochrome C Oxidase and Systemic Changes Indicates Injury Severity in Neonatal Encephalopathy. Adv Exp Med Biol. 2016;923:181-186.
  • Mitra S, Bale G, Mathieson S, Uria-Avellanal C, Meek J, Tachtsidis I, Robertson NJ. Changes in Cerebral Oxidative Metabolism during Neonatal Seizures Following Hypoxic-Ischemic Brain Injury. Front Pediatr. 2016 Aug 10;4:83.
  • Mitra S, Bale G, Meek J, Mathieson S, Uria C, Kendall G, Robertson NJ, Tachtsidis I. In Vivo Measurement of Cerebral Mitochondrial Metabolism Using Broadband Near Infrared Spectroscopy Following Neonatal Stroke. Adv Exp Med Biol. 2016;876:493-500.
  • da Costa CS, Czosnyka M, Smielewski P, Mitra S, Stevenson GN, Austin T. Monitoring of Cerebrovascular Reactivity for Determination of Optimal Blood Pressure in Preterm Infants. J Pediatr. 2015 Jul;167(1):86-91.
  • Bale G, Mitra S, Meek J, Robertson N, Tachtsidis I. A new broadband near-infrared spectroscopy system for in-vivo measurements of cerebral cytochrome-c-oxidase changes in neonatal brain injury. Biomed Opt Express. 2014 Sep 5;5(10):3450-66.
  • Mitra S, Czosnyka M, Smielewski P, O'Reilly H, Brady K, Austin T. Heart rate passivity of cerebral tissue oxygenation is associated with predictors of poor outcome in preterm infants. Acta Paediatr. 2014 Sep;103(9):e374-82.
  • Mitra S, Dove J, Somisetty SK. Subcutaneous fat necrosis in newborn-an unusual case and review of literature. Eur J Pediatr. 2011 Sep;170(9):1107-10.
  • Cooper RJ, Hebden JC, O'Reilly H, Mitra S, Michell AW, Everdell NL, Gibson AP, Austin T. Transient haemodynamic events in neurologically compromised infants: a simultaneous EEG and diffuse optical imaging study. Neuroimage. 2011 Apr 15;55(4):1610-6.