Photo of Professor Robert Heyderman

Professor Robert Heyderman

Telephone:

Email:

Location:

  • University College Hospital
  • Hospital for Tropical Diseases

GMC/GDC number:

3056444

Professional background

I am a clinician scientist with skills and experience that bridge clinical practice, disease prevention and fundamental understanding of the mechanisms of infectious disease. I trained in infectious diseases and general internal medicine in London and Zimbabwe. I directed the highly successful Malawi-Liverpool-Wellcome Trust Programme (MLW) for more than eight years, transforming the programme into a centre of excellence led by Malawian and international scientists, pursuing internationally-leading science, research training and improving the health of people in sub-Saharan Africa.

Since joining UCL and UCLH, I have launched the NIHR Global Health Research Unit on Mucosal Pathogens (MPRU), which is an interdisciplinary translational programme. This brings together internationally recognised UK and African investigators to tackle limitations in the long-term effectiveness of existing vaccines to prevent meningitis, pneumonia and sepsis though new approaches to interrupting mucosal pathogen carriage/transmission.

Specialties

Publications

PUBLICATIONS IN THE LAST 2 YEARS (>290 publications)

  • Connor MG, Camarasa T, Patey E, Rasid O, Barrio L, Weight CM, Miller DP, Heyderman RS, Lamont RJ, Enninga J, Hamon mA The histone demethylase KDM6B fine-tunes the host response to Streptococcus pneumoniae. Nat Microbiol 2020 In press.
  • MacCormick IJC, Barrera V, Beare NAV, Czanner G, Potchen M, Kampondeni S, Heyderman RS, Craig AG, Molyneux ME, Mallewa M, White VA, Milner D, Hiscott P, Taylor TE, Seydel KB, Harding SP. How Does Blood-Retinal Barrier Breakdown Relate to Death and Disability in Pediatric Cerebral Malaria? J Infect Dis. 2020 In press.
  • Williams S, Sheikh A, Campbell H, Fitch N, Griffiths C, Heyderman RS, Jordan RE, Katikireddi SV, Tsiligianni I, Obasi A, Global Health Respiratory N. Respiratory research funding is inadequate, inequitable, and a missed opportunity. Lancet Respir Med. 2020;8:e67-e8.
  • Olgemoeller F, Waluza JJ, Zeka D, Gauld JS, Diggle PJ, Read JM, Edwards T, Msefula CL, Chirambo A, Gordon MA, Thomson E, Heyderman RS, Borgstein E, Feasey NA. Intestinal Perforations Associated With a High Mortality and Frequent Complications During an Epidemic of Multidrug-resistant Typhoid Fever in Blantyre, Malawi. Clin Infect Dis. 2020;71:S96-S101.
  • Carey ME, MacWright WR, Im J, Meiring JE, Gibani MM, Park SE, Longley A, Jeon HJ, Hemlock C, Yu AT, Soura A, Aiemjoy K, Owusu-Dabo E, Terferi M, Islam S, Lunguya O, Jacobs J, Gordon M, Dolecek C, Baker S, Pitzer VE, Yousafzai MT, Tonks S, Clemens JD, Date K, Qadri F, Heyderman RS, Saha SK, Basnyat B, Okeke IN, Qamar FN, Voysey M, Luby S, Kang G, Andrews J, Pollard AJ, John J, Garrett D, Marks F. The Surveillance for Enteric Fever in Asia Project (SEAP), Severe Typhoid Fever Surveillance in Africa (SETA), Surveillance of Enteric Fever in India (SEFI), and Strategic Typhoid Alliance Across Africa and Asia (STRATAA) Population-based Enteric Fever Studies: A Review of Methodological Similarities and Differences. Clin Infect Dis. 2020;71:S102-S10.
  • Nyazika TK, Law A, Swarthout TD, Sibale L, Ter Braake D, French N, Heyderman RS , Everett D, Kadioglu A, Jambo KC, Neill DR. Influenza-like illness is associated with high pneumococcal carriage density in Malawian children. J Infect. 2020 In press.
  • Rodgers E, Bentley SD, Borrow R, Bratcher HB, Brisse S, Brueggemann AB, Caugant DA, Findlow J, Fox L, Glennie L, Harrison LH, Harrison OB, Heyderman RS, van Rensburg MJ, Jolley KA, Kwambana-Adams B, Ladhani S, LaForce M, Levin M, Lucidarme J, MacAlasdair N, Maclennan J, Maiden MCJ, Maynard-Smith L, Muzzi A, Oster P, Rodrigues CMC, Ronveaux O, Serino L, Smith V, van der Ende A, Vazquez J, Wang X, Yezli S, Stuart JM. The global meningitis genome partnership. J Infect. 2020 In press.
  • Gori A, Harrison OB, Mlia E, Nishihara Y, Chan JM, Msefula J, Mallewa M, Dube Q, Swarthout TD, Nobbs AH, Maiden MCJ, French N, Heyderman RS. Pan-GWAS of Streptococcus agalactiae Highlights Lineage-Specific Genes Associated with Virulence and Niche Adaptation. mBio. 2020;11:e00728-20.
  • Swarthout TD, Fronterre C, Lourenco J, Obolski U, Gori A, Bar-Zeev N, Everett D, Kamng'ona AW, Mwalukomo TS, Mataya AA, Mwansambo C, Banda M, Gupta S, Diggle P, French N, Heyderman RS. High residual carriage of vaccine-serotype Streptococcus pneumoniae after introduction of pneumococcal conjugate vaccine in Malawi. Nat Commun. 2020;11:2222.
  • Kelly C, Tinago W, Alber D, Hunter P, Luckhurst N, Connolly J, Arrigoni F, Abner AG, Kamngona R, Sheha I, Chammudzi M, Jambo K, Mallewa J, Rapala A, Heyderman RS, Mallon PWG, Mwandumba H, Walker AS, Klein N, Khoo S. Inflammatory Phenotypes Predict Changes in Arterial Stiffness following ART Initiation. Clin Infect Dis. 2020 In press.
  • Lester R, Haigh K, Wood A, MacPherson EE, Mahewswaran H, Bogue P, Hanger S, Kalizang'oma A, Srirathan V, Kulpani D, Mallewa J, Nyirenda M, Jewell CP, Heyderman R, Gordon M, Lalloo DG, Tolhurst R, Feasey NA. Sustained reduction in third-generation cephalosporin usage in adult inpatients following introduction of an antimicrobial stewardship program in a large urban hospital in Malawi. Clin Infect Dis. 2020 In press.
  • Kanyama C, Molloy SF, Chan AK, Lupiya D, Chawinga C, Adams J, Bright P, Lalloo DG, Heyderman RS, Lortholary O, Jaffar S, Loyse A, van Oosterhout JJ, Hosseinipour MC, Harrison TS. One-year Mortality Outcomes From the Advancing Cryptococcal Meningitis Treatment for Africa Trial of Cryptococcal Meningitis Treatment in Malawi. Clin Infect Dis. 2020;70:521-4.
  • Gauld JS, Olgemoeller F, Nkhata R, Li C, Chirambo A, Morse T, Gordon MA, Read JM, Heyderman RS, Kennedy N, Diggle PJ, Feasey NA. Domestic River Water Use and Risk of Typhoid Fever: Results From a Case-control Study in Blantyre, Malawi. Clin Infect Dis. 2020;70:1278-84.
  • Chaguza C, Heinsbroek E, Gladstone RA, Tafatatha T, Alaerts M, Peno C, Cornick JE, Musicha P, Bar-Zeev N, Kamng'ona A, Kadioglu A, McGee L, Hanage WP, Breiman RF, Heyderman RS, French N, Everett DB, Bentley SD. Early Signals of Vaccine-driven Perturbation Seen in Pneumococcal Carriage Population Genomic Data. Clin Infect Dis. 2020;70:1294-303.
  • Shiri T, Loyse A, Mwenge L, Chen T, Lakhi S, Chanda D, Mwaba P, Molloy SF, Heyderman RS, Kanyama C, Hosseinipour MC, Kouanfack C, Temfack E, Mfinanga S, Kivuyo S, Chan AK, Jarvis JN, Lortholary O, Jaffar S, Niessen LW, Harrison TS. Addition of Flucytosine to Fluconazole for the Treatment of Cryptococcal Meningitis in Africa: A Multicountry Cost-effectiveness Analysis. Clin Infect Dis. 2020 Jan 1;70:26-9.
  • Weight C, Venturini C, Pojar S, Jochems SP, Reiné J, Nikolaou E, Noursadeghi M, Brown JS, Ferreira DM, Heyderman RS. Epithelial micro-invasion by Streptococcus pneumoniae induces epithelial-derived innate immunity during colonisation at the human mucosal surface. Nature Communications 2019; 10:3060
  • Jochems SP, de Ruiter K, Solorzano C, Voskamp A, Mitsi E, Nikolaou E, Carniel BF, Pojar S, German EL, Reine J, Soares-Schanoski A, Hill H, Robinson R, Hyder-Wright AD, Weight CM, Durrenberger PF, Heyderman RS, Gordon SB, Smits HH, Urban BC, Rylance J, Collins AM, Wilkie MD, Lazarova L, Leong SC, Yazdanbakhsh M, Ferreira DM. Innate and adaptive nasal mucosal immune responses following experimental human pneumococcal colonization. J Clin Invest. 2019; 130: 4523-4538
  • Struyf T, Dube Q, Cromwell EA, Sheahan AD, Heyderman RS, Van Rie A. The effect of HIV infection and exposure on cognitive development in the first two years of life in Malawi. EJPN 2019 In Press
  • Sheikh A, Campbell H, Balharry D, Adab P, Barreto ML, Bauld L, Cooper P, Cruz A, Davidson FM, Dodd P, Enocson A, Fitch N, Griffiths C, Grigg J, Heyderman RS, Jordan R, Katikireddi SV, Kuo S, Kwambana-Adams B, Leyland AH, Mortimer K, Mosler G, Obasi A, Orme M, Readshaw A, Savio M, Siddiqi K, Sifaki-Pistolla D, Singh S, Squire B, Tsiligianni I, Williams S. The UK's Global Health Respiratory Network: Improving respiratory health of the world's poorest through research collaborations. J Glob Health 2019;9:020104
  • Peterson I, Ntsui N, Jambo K, Kelly C, Huwa J, Afran L, Tatuene JK, Pett S, Henrion MYR, Van Oosterhout J, Heyderman RS, Mwandumba H, Benjamin LA, Investigators of the Rs. Evaluating the reactivation of herpesviruses and inflammation as cardiovascular and cerebrovascular risk factors in antiretroviral therapy initiators in an African HIV-infected population (RHICCA): a protocol for a longitudinal cohort study. BMJ Open 2019 Sep 12;9:e025576
  • Lourenco J, Obolski U, Swarthout TD, Gori A, Bar-Zeev N, Everett D, Kamng'ona AW, Mwalukomo TS, Mataya AA, Mwansambo C, Banda M, Gupta S, French N, Heyderman RS. Determinants of high residual post-PCV13 pneumococcal vaccine-type carriage in Blantyre, Malawi: a modelling study. BMC Med. 2019 Dec 5;17:219
  • Kalata NL, Nyazika TK, Swarthout TD, Everett D, French N, Heyderman RS, Gordon SB, Jambo KC. Pneumococcal pneumonia and carriage in Africa before and after introduction of pneumococcal conjugate vaccines, 2000-2019: protocol for systematic review. BMJ Open 2019;9:e030981.
  • Ho A, Mapurisa G, Madanitsa M, Kalilani-Phiri L, Kamiza S, Makanani B, Ter Kuile FO, Buys A, Treurnicht F, Everett D, Mwapasa V, Widdowson MA, McMorrow M, Heyderman RS. Impact of Maternal HIV Infection and Placental Malaria on the Transplacental Transfer of Influenza Antibodies in Mother-Infant Pairs in Malawi, 2013-2014. Open Forum Infect Dis. 2019;6: 383.
  • Ellis J, Luintel A, Chandna A, Heyderman RS. Community-acquired acute bacterial meningitis in adults: a clinical update. Br Med Bull. 2019;131:57-70
  • Jere KC, Bar-Zeev N, Chande A, Bennett A, Pollock L, Sanchez-Lopez PF, Nakagomi O, Tate JE, Parashar UD, Heyderman RS, French N, Iturriza-Gomara M, Cunliffe NA. Vaccine Effectiveness against DS-1-Like Rotavirus Strains in Infants with Acute Gastroenteritis, Malawi, 2013-2015. Emerg Infect Dis. 2019;25:1734-7.
  • Miles DJC, Shumba F, Pachnio A, Begum J, Corbett EL, Heyderman RS, Moss P. Early T Cell Differentiation with Well-Maintained Function across the Adult Life Course in Sub-Saharan Africa. J Immunol. 2019; 203: 1160-1171 (Joint last author)
  • Msefula CL, Olgemoeller F, Jambo N, Segula D, Van Tan T, Nyirenda TS, Nedi W, Kennedy N, Graham M, Henrion MYR, Baker S, Feasey N, Gordon M, Heyderman RS. Ascertaining the burden of invasive Salmonella disease in hospitalised febrile children aged under four years in Blantyre, Malawi. PLoS Negl Trop Dis. 2019;13:e0007539.
  • Chen T, Mwenge L, Lakhi S, Chanda D, Mwaba P, Molloy SF, Gheorghe A, Griffiths UK, Heyderman RS, Kanyama C, Kouanfack C, Mfinanga S, Chan AK, Temfack E, Kivuyo S, Hosseinipour MC, Lortholary O, Loyse A, Jaffar S, Harrison TS, Niessen LW, Team AT. Healthcare Costs and Life-years Gained From Treatments Within the Advancing Cryptococcal Meningitis Treatment for Africa (ACTA) Trial on Cryptococcal Meningitis: A Comparison of Antifungal Induction Strategies in Sub-Saharan Africa. Clin Infect Dis. 2019 In Press.
  • Obolski U, Gori A, Lourenco J, Thompson C, Thompson R, French N, Heyderman RS, Gupta S. Identifying genes associated with invasive disease in S. pneumoniae by applying a machine learning approach to whole genome sequence typing data. Sci Rep. 2019;9:4049.
  • Meiring JE, Laurens MB, Patel P, Patel P, Misiri T, Simiyu K, Mwakiseghile F, Tracy JK, Masesa C, Liang Y, Henrion M, Rotrosen E, Gmeiner M, Heyderman R, Kotloff K, Gordon MA, Neuzil KM. Typhoid Vaccine Acceleration Consortium Malawi: A Phase III, Randomized, Double-blind, Controlled Trial of the Clinical Efficacy of Typhoid Conjugate Vaccine Among Children in Blantyre, Malawi. Clin Infect Dis. 2019;68:S50-S8.
  • Musicha P, Msefula CL, Mather AE, Chaguza C, Cain AK, Peno C, Kallonen T, Khonga M, Denis B, Gray KJ, Heyderman RS, Thomson NR, Everett DB, Feasey NA. Genomic analysis of Klebsiella pneumoniae isolates from Malawi reveals acquisition of multiple ESBL determinants across diverse lineages. J Antimicrob Chemother. 2019; 74: 1223-1232
  • Bennett A, Pollock L, Jere KC, Pitzer VE, Lopman B, Parashar U, Everett D, Heyderman RS, Bar-Zeev N, Cunliffe NA, Iturriza-Gomara M. Infrequent Transmission of Monovalent Human Rotavirus Vaccine Virus to Household Contacts of Vaccinated Infants in Malawi. J Infect Dis. 2019; 219:219:1730-1734
  • Kelly C, Mwandumba HC, Heyderman RS, Jambo K, Kamng'ona R, Chammudzi M, Sheha I, Peterson I, Rapala A, Mallewa J, Walker AS, Klein N, Khoo S. HIV-related arterial stiffness in Malawian adults is associated with proportion of PD-1 expressing CD8 T-cells and reverses with anti-retroviral therapy. J Infect Dis 2019; 219: 1948-1958
  • Aston SJ, Ho A, Jary H, Huwa J, Mitchell T, Ibitoye S, Greenwood S, Joekes E, Daire A, Mallewa J, Everett D, Nyirenda M, Faragher B, Mwandumba HC, Heyderman RS, Gordon SB. Aetiology and Risk Factors for Mortality in an Adult Community-Acquired Pneumonia Cohort in Malawi. Am J Respir Crit Care Med. 2019; 200: 359-369
  • Pollock L, Bennett A, Jere KC, Dube Q, Mandolo J, Bar-Zeev N, Heyderman RS, Cunliffe NA, Iturriza-Gomara M. Non-secretor histo-blood group antigen phenotype is associated with reduced risk of clinical rotavirus vaccine failure in Malawian infants. Clin Infect Dis. 2018; 69: 1313-1319.
  • Loyse A, Burry J, Cohn J, Ford N, Chiller T, Ribeiro I, Koulla-Shiro S, Mghamba J, Ramadhani A, Nyirenda R, Aliyu SH, Wilson D, Le T, Oladele R, Lesikari S, Muzoora C, Kalata N, Temfack E, Mapoure Y, Sini V, Chanda D, Shimwela M, Lakhi S, Ngoma J, Gondwe-Chunda L, Perfect C, Shroufi A, Andrieux-Meyer I, Chan A, Schutz C, Hosseinipour M, Van der Horst C, Klausner JD, Boulware DR, Heyderman R, Lalloo D, Day J, Jarvis JN, Rodrigues M, Jaffar S, Denning D, Migone C, Doherty M, Lortholary O, Dromer F, Stack M, Molloy SF, Bicanic T, van Oosterhout J, Mwaba P, Kanyama C, Kouanfack C, Mfinanga S, Govender N, Harrison TS. Leave no one behind: response to new evidence and guidelines for the management of cryptococcal meningitis in low-income and middle-income countries. Lancet Infect Dis. 2019;19: e143-e147
  • Iroh Tam PY, Musicha P, Kawaza K, Cornick J, Denis B, Freyne B, Everett D, Dube Q, French N, Feasey N, Heyderman R. Emerging resistance to empiric antimicrobial regimens for pediatric bloodstream infections in Malawi (1998-2017). Clin Infect Dis. 2019;69:61-68