Professor Karl Frontzek
Telephone:
Email:
Location:
- National Hospital for Neurology and Neurosurgery
GMC/GDC number:
7925395
Professional background
Dr Karl Frontzek provides regular diagnostic neuropathology service in neurooncological, neurodegenerative and neuromuscular disease at the National Hospital of Neurology and Neurosurgery. He as a special research interest in molecular pathology of neurodegenerative disease. Alongside his clinical and academic interests, he is committed to providing regular medical, post-graduate education.
Appointments
2023 – Clinical Associate Professor of Neuropathology, University College London, Institute of Neurology
2023 – Honorary Neuropathologist, University College London Hospitals and Great Ormond Street Hospital NHS Foundation Trusts
2022 – Visiting Faculty Member, Weizmann Institute of Science
2019 – Consultant Neuropathologist, University Hospital Zurich
Qualifications
2022 - Certificate of Eligibility for Specialist Registration (CESR) in Diagnostic Neuropathology, General Medical Council
2019 – Board Certification in Neuropathology, Swiss Medical Association
2017 – PhD, University of Zurich
2014 – MD, University of Basel
2010 – Human Medicine State Exam, Georg-August-University Göttingen
Specialties
Research interests
Molecular neuropathology of movement disorders and dementia.
Languages spoken
German, French, Polish
Publications
Frontzek, K., M. Bardelli, A. Senatore, A. Henzi, R. R. Reimann, S. Bedir, M. Marino, R. Hussain, S. Jurt, G. Meisl, M. Pedotti, F. Mazzola, G. Siligardi, O. Zerbe, M. Losa, T. Knowles, A. Lakkaraju, C. Zhu, P. Schwarz, S. Hornemann, M. G. Holt, L. Simonelli, L. Varani, and A. Aguzzi. "A Conformational Switch Controlling the Toxicity of the Prion Protein." Nat Struct Mol Biol 29, no. 8 (Aug 2022): 831-40.
Frontzek, K., M. Carta, M. Losa, M. Epskamp, G. Meisl, A. Anane, J. P. Brandel, U. Camenisch, J. Castilla, S. Haik, T. Knowles, E. Lindner, A. Lutterotti, E. V. Minikel, I. Roiter, J. G. Safar, R. Sanchez-Valle, D. Zakova, S. Hornemann, A. Aguzzi, and Thautan-Mc Study Group. "Autoantibodies against the Prion Protein in Individuals with Prnp Mutations." Neurology 95, no. 14 (Oct 6 2020): e2028-e37.
Kirschenbaum, D., L. L. Imbach, E. J. Rushing, K. B. M. Frauenknecht, D. Gascho, B. V. Ineichen, E. Keller, S. Kohler, M. Lichtblau, R. R. Reimann, K. Schreib, S. Ulrich, P. Steiger, A. Aguzzi, and K. Frontzek. "Intracerebral Endotheliitis and Microbleeds Are Neuropathological Features of Covid-19." Neuropathol Appl Neurobiol 47, no. 3 (Apr 2021): 454-59.
Kirschenbaum, D., L. L. Imbach, S. Ulrich, E. J. Rushing, E. Keller, R. R. Reimann, K. B. M. Frauenknecht, M. Lichtblau, M. Witt, T. Hummel, P. Steiger, A. Aguzzi, and K. Frontzek. "Inflammatory Olfactory Neuropathy in Two Patients with Covid-19." Lancet 396, no. 10245 (Jul 18 2020): 166.
Aguzzi, A., and K. Frontzek. "New Paradigms of Clinical Trial Design for Genetic Prion Diseases." Lancet Neurol 19, no. 4 (Apr 2020): 284-85.