Professor Hannah Cohen

Selected publications 2015-2020:

Cohen H, Isenberg D. How I treat anticoagulant-refractory thrombotic antiphospholipid syndrome. Blood. 2020. doi:10.1182/blood.2020004942

Sayar Z, Moll R, Isenberg D, Cohen H.
Thrombotic antiphospholipid syndrome: a practical guide to diagnosis and management.
Thrombosis Research. 2020; In Press.

Cohen H, Cuadrado MJ, Erkan D,...Andrade, D. 16th International Congress on Antiphospholipid Antibodies Task Force Report on Antiphospholipid Syndrome Treatment Trends. Lupus. 2020; 29(12): 1571-1593.

Devreese KMJ, de Groot PG,…Cohen, H. Guidance from the Scientific and Standardization Committee for lupus anticoagulant/antiphospholipid antibodies of the International Society on Thrombosis and Haemostasis: Update of the guidelines for lupus anticoagulant detection and interpretation. J Thromb Haemost. 2020; 18(11): 2828-2839.

Cohen H, Sayar Z, Efthymiou M, Gaspar P, Richards T, Isenberg D. Management of anticoagulant-refractory thrombotic antiphospholipid syndrome. Lancet Haematol. 2020; 7(8): e613-e623.

Zuily S, Cohen H, Isenberg D,…Devreese KMJ. Use of direct oral anticoagulants in patients with thrombotic antiphospholipid syndrome: Guidance from the Scientific and Standardization Committee of the International Society on Thrombosis and Haemostasis. J Thromb Haemost. 2020; 18(9), 2126-2137.

Tripodi A, Cohen H, & Devreese KMJ. Lupus anticoagulant detection in anticoagulated patients. Guidance from the Scientific and Standardization Committee for lupus anticoagulant/antiphospholipid antibodies of the International Society on Thrombosis and Haemostasis. J Thromb Haemost. 2020; 18(7): 1569-1575.

Gaspar P, Cohen H, Isenberg DA. The assessment of patients with the antiphospholipid antibody syndrome: where are we now? Rheumatology. 2020; 59(7): 1489-1494.

Sevim E, Zisa D, Andrade D,…Cohen H,… Barbhaiya M, APS ACTION Investigators. Characteristics of Antiphospholipid Antibody Positive Patients in AntiPhospholipid Syndrome Alliance for Clinical Trials and InternatiOnal Networking. Arthritis Care Res (Hoboken). doi:10.1002/acr.24468

Schreiber K, Sciascia S, Bruce I…Cohen H,…Hunt BJ. Hydroxychloroquine in patients with rheumatic diseases during the COVID-19 pandemic: a letter to clinicians. Lancet Rheumatol. 2020. doi:10.1016/S2665-9913(20)30382-9

Ramirez GA, Mackie I, Nallamilli S…Cohen H, Efthymiou M. Anti-protein C antibodies and acquired protein C resistance in SLE: novel markers for thromboembolic events and disease activity? Rheumatology (Oxford). 2020. doi:10.1093/rheumatology/keaa509

Amin T, Cohen H, Wong M, Goodhart V, Pointer S-L, Jurkovic D. The prevalence of incidental uterine venous plexus thrombosis in women attending a gynecology clinic. J Thromb Haemost. 2020; 18(10), 2557-2565.

Ulivi L, Squitieri M, Cohen H,…Werring DJ. Cerebral venous thrombosis: a practical guide. Pract Neurol. 2020; 20 (5) pp. 356-367.

Best JG, Barbato C, Ambler G,…Cohen H,…Werring D. Clinical Relevance of Microbleeds in Stroke (CROMIS-2) collaborators. Association of enlarged perivascular spaces and anticoagulant-related intracranial hemorrhage. Neurology. 2020; 95; e2192-e2199.

Zuily S, Clerc-Urmes I, Bauman C,…Cohen H…Erkan, D. Cluster analysis for the identification of clinical phenotypes among antiphospholipid antibody-positive patients from the APS ACTION Registry. Lupus. 2020; 29(11) 1353–1363.

Beyrouti R, Adams ME,…Cohen H,…Werring DJ. Characteristics of ischaemic stroke associated with COVID-19. J Neurol Neurosurg Psychiatry. 2020. J Neurol Neurosurg Psychiatry 2020; 91: 889-891.

Banerjee G, Chan E, Ambler G,…Cohen H,…Werring DJ. Cognitive Impairment Before Atrial Fibrillation-Related Ischemic Events: Neuroimaging and Prognostic Associations. J Am Heart Assoc. 2020; 9(1): e014537. doi:10.1161/JAHA.119.014537

Cohen H, Efthymiou M, Isenberg DA. Use of direct oral anticoagulants in antiphospholipid syndrome: Reply. J Thromb Haemost. 2020; 18(1): 259-261.

Cohen H. The use of direct oral anticoagulants in antiphospholipid syndrome. Clini Adv Hematol Onc. 2020; 18(1): 19-23.

Radin M, Sciascia S, Erkan D,…Cohen H,…Andrade D, APS ACTION. The adjusted global antiphospholipid syndrome score (aGAPSS) and the risk of recurrent thrombosis: Results from the APS ACTION cohort. Seminars in Arthritis and Rheumatism. 2019; 49(3): 464-468.

Efthymiou M, Mackie IJ, Lane P…Cohen H. APS ACTION. Comparison of real world and core laboratory lupus anticoagulant results from the Antiphospholipid Syndrome Alliance for Clinical Trials and International Networking (APS ACTION) clinical database and repository. J Thromb Haemost. 2019; 17:2069-2080.

McDonnell T, Wincup C, Buchholz I,…Cohen H, Rahman, A. The role of beta-2-glycoprotein I in health and disease associating structure with function: More than just APS. Blood Reviews. 2019; doi:10.1016/j.blre.2019.100610

Cohen H, Mackie IJ, Devreese KMJ. Clinical and laboratory practice for lupus anticoagulant testing: An International Society of Thrombosis and Haemostasis Scientific and Standardization Committee survey. J Thromb Haemost. 2019; 17(10), 1715-1732.

Ramirez GA, Efthymiou M, Isenberg DA, Cohen H. Under crossfire: thromboembolic risk in systemic lupus erythematosus. Rheumatology. 2019; 58(6): 940–952.

Wilson D, Ambler G, Lee K-J,…Cohen H,…Werring D. Microbleeds International Collaborative Network. Cerebral microbleeds and stroke risk after ischaemic stroke or transient ischaemic attack: a pooled analysis of individual patient data from cohort studies. Lancet Neurol. 2019; 18(7): P653-665.

Banerjee G, Chan E, Ambler ,…Cohen H,…Werring DJ. Effect of small-vessel disease on cognitive trajectory after atrial fibrillation-related ischaemic stroke or TIA. J Neurology. 2019; 266(5), 1250-1259.

Sciascia S, Willis R, Pengo V,…Cohen H,…Bertolaccini LM,…APS ACTION. The comparison of real world and core laboratory antiphospholipid antibody ELISA results from antiphospholipid syndrome alliance for clinical trials & international networking (APS ACTION) clinical database and repository analysis. Thromb Res. 2019; 175, 32-36.

Wilson D, Ambler G, Banerjee G,…Cohen H,…Werring D,….Clinical relevance of Microbleeds in Stroke (CROMIS-2) collaborators. Early versus late anticoagulation for ischaemic stroke associated with atrial fibrillation: multicentre cohort study. J Neurol Neurosurg Psychiatry. 2019; 90:320-325.

Efthymiou M, Arachchillage DRJ, Lane PJ,…Cohen H, Mackie IJ. Antibodies against TFPI and protein C are associated with a severe thrombotic phenotype in patients with and without antiphospholipid syndrome. Thromb Res. 2018; 170: 60-68.

de Jesus GR, Sciascia S, Andrade D,…Cohen H,…Levy RA, APS ACTION. Factors associated with first thrombosis in patients presenting with obstetric antiphospholipid syndrome (APS) in the APS Alliance for Clinical Trials and International Networking Clinical Database and Repository: a retrospective study. BJOG-An international journal of obstetrics and gynaecology. 2019; 126(5): 656-661.

Wilson D, Ambler G, Shakeshaft,C,…Cohen H,…Werring DJ. Cerebral microbleeds and intracranial haemorrhage risk in patients anticoagulated for atrial fibrillation after acute ischaemic stroke or transient ischaemic attack (CROMIS-2): a multicentre observational cohort study. Lancet Neurology. 2018; 17(6): 539-547.

Cohen H, Efthymiou M, Isenberg D. Use of direct oral anticoagulants in antiphospholipid syndrome. Journal Thromb Haemost. 2018; 16: 1028–1039.

Giles IP, Cohen H, Ioannou Y. Pathogenesis of antiphospholipid antibody syndrome. In: Wallace DJ, Hahn BH, eds. Dubois’ Lupus Erythematosus and Related Syndromes. 9th ed. St. Lois, MO: Elsevier; 2019:324-337.

Willis R, Cohen H, Giles IP, Knight J, Krilis S, Rahman A, de Groot P. Mechanisms of antiphospholipid antibody mediated thrombosis. In D. Erkan, & R. Willis (Eds.). Antiphospholipid Syndrome: Insights and Highlights from the 15th International Congress on Antiphospholipid Antibodies. Springer. New York. 2017:77-116.

Cohen H, Hunt BJ, Efthymiou M, Mackie IJ, Khamashta M, Isenberg DA. Direct Oral Anticoagulants Use in Antiphospholipid Syndrome: Are These Drugs an Effective and Safe Alternative to Warfarin? A Systematic Review of the Literature: Comment. Current Rheumatology Reports. 2017; 19(8). doi:10.1007/s11926-017-0675-3

Schreiber K, Breen K, Cohen H,…Hunt BJ. HYdroxychloroquine to Improve Pregnancy Outcome in Women with AnTIphospholipid Antibodies (HYPATIA) Protocol: A Multinational Randomized Controlled Trial of Hydroxychloroquine versus Placebo in Addition to Standard Treatment in Pregnant Women with Antiphospholipid Syndrome or Antibodies. Sem Thromb Haemost; 43(6), 562-571.

Cohen H, Efthymiou M, Gates C, Isenberg D. Direct Oral Anticoagulants for Thromboprophylaxis in Patients with Antiphospholipid Syndrome. Sem Thromb Hemost. 2017; 44(5):427-438.

Cohen H, Arachchillage DR, Middeldorp S, Beyer-Westendorf J, Abdul-Kadir R. Management of direct oral anticoagulants in women of childbearing potential: Guidance from the SSC of the ISTH: Reply. Journal of Thrombosis and Haemostasis. 2017; 15(1); 195-197.

Arachchillage DR Mackie IJ, Efthymiou M,…Cohen, H. Rivaroxaban limits complement activation compared with warfarin in antiphospholipid syndrome patients with venous thromboembolism. J Thromb Haemost. 2016; 14(11); 2177-2186.

Cohen H, Arachchillage DRJ, Beyer-Westendorf J, Middeldorp S, Kadir RA. Direct Oral Anticoagulants and Women. Sem Thromb Haemost. 2016; 42(7): 789-797.

Beyer-Westendorf J, Michalski F, Tittl L,…Cohen H,…Marten S. Pregnancy outcome in patients exposed to direct oral anticoagulants - and the challenge of event reporting. Thromb Haemost. 2016; 116(4): 651-658.

Cohen H, Hunt BJ, Efthymiou M,…Isenberg DA. Rivaroxaban versus warfarin to treat patients with thrombotic antiphospholipid syndrome, with or without systemic lupus erythematosus (RAPS): a randomised, controlled, open-label, phase 2/3, non-inferiority trial. Lancet Haematol. 2016; 3(9), E426-E436.

Cohen H, Arachchillage DR, Middeldorp S, Beyer-Westendorf J, Abdul-Kadir R. Management of direct oral anticoagulants in women of childbearing potential: guidance from the SSC of the ISTH. J Thromb Haemost. 2016; 14(8): 1673-1676.

Engert A, Balduini C, Brand A,…Cohen H,…Schuringa, the other authors of the EHA Roadmap for European Hematology Research. The European Hematology Association roadmap for European hematology research: a consensus document. Haematologica. 2016; 101(2): 115-208.

Wilson D, Charidimou A, Shakeshaft C,…Cohen H,…Werring DJ. Volume and functional outcome of intracerebral hemorrhage associated with non-vitamin K oral anticoagulants compared to warfarin: Multicenter cross sectional observational study. Int J of Stroke. 2016; 10: 59-60.

Wilson D, Charidimou A, Shakeshaft C,…Cohen H,…Werring DJ. Volume and functional outcome of intracerebral hemorrhage according to oral anticoagulant type. Neurology. 2016; 86(4), 360-366.

Arachchillage D, Cohen, H. Recurrent miscarriages and neurological symptoms. In Stroke Medicine: Case Studies from Queen Square; 2015: 43-49. doi:10.1007/978-1-4471-6705-

Cohen H, & O'Brien P. (Eds.) Disorders of thrombosis and haemostasis in pregnancy: a guide to management (2nd ed.). 2015; London: Springer. doi:10.1007/978-3-319-15120-5

Arachchillage DRJ, Mackie IJ, Efthymiou M,…Cohen H. Interactions between rivaroxaban and antiphospholipid antibodies in thrombotic antiphospholipid syndrome. J Thromb Haemost. 2015; 13(7): 1264-1273.

Cohen H, Dore CJ, Clawson S,….Muirhead N. Rivaroxaban in antiphospholipid syndrome (RAPS) protocol: a prospective, randomized controlled phase II/III clinical trial of rivaroxaban versus warfarin in patients with thrombotic antiphospholipid syndrome, with or without SLE. Lupus. 2015; 24(10), 1087-1094.

Efthymiou M, Lawrie AS, Mackie I,…Cohen H. Thrombin generation and factor X assays for the assessment of warfarin anticoagulation in thrombotic antiphospholipid syndrome. Thromb Res. 2015; 135(6), 1191-1197.

Arachchillage DRJ, Efthymiou M, Mackie IJ, Lawrie AS, Machin SJ, Cohen, H. Rivaroxaban and warfarin achieve effective anticoagulation, as assessed by inhibition of TG and in-vivo markers of coagulation activation, in patients with venous thromboembolism. Thromb Res. 2015; 135(2), 388-393.

Arachchillage DRJ, Machin SJ, Mackie IJ, Cohen H. Diagnosis and management of non-criteria obstetric antiphospholipid syndrome. Thromb Haemost. 2015; 113(1): 13-19.