Dr Marc George
Telephone:
Location:
- University College Hospital
GMC/GDC number:
6158675
Professional background
Dr Marc George is a consultant in General (Internal) Medicine and Clinical Pharmacology at UCLH and Honorary Associate Professor at the UCL Institute of Cardiovascular Sciences.
He is the Clinical Lead for the Blood Pressure and Cardiovascular Risk clinic where he has expertise in early-onset, resistant and secondary hypertension and cholesterol management. His inpatient work includes Acute and Internal Medicine.
Dr George is the Trust Lead for Medical Emergency Guidelines and sits on the UCLH Clinical Guidelines and Use of Medicines Committees.
At UCL he is a module lead within the iBSc in Cardiovascular Sciences and provides teaching on several under and post-graduate degree courses including MBBS.
Specialties
Research interests
Dr George’s research interest is in developing new approaches to treating cardiovascular disease including targeting inflammation and high blood pressure.
He completed his PhD in 2019 developing a potential new treatment for heart attacks (Interleukin-6 trans-signalling blockade). This work was published in ‘JACC basic to translational science’ and received several prizes including the ‘Best PhD Oral Presentation Winner’ at the British Pharmacological Society Pharmacology Futures conference 2018, London Cardiovascular Society ‘Young Investigator of the Year’ 2018 and UCL Division of Medicine ‘Best PhD Upgrade Presentation’ Award 2016-17.
Dr George is currently the local Principal Investigator for a multicentre blood pressure trial funded by the British Heart Foundation.
Publications
George MJ, Jasmin NH, Taylor Cummings V, Richard-Loendt A, Launchbury F, Woollard K, Turner-Stokes T, Diaz AIG, Lythgoe M, Stuckey DJ, Hingorani AD, Gilroy DW. Selective interleukin-6 trans-signalling blockade is more efficacious than pan-antagonism in reperfused myocardial infarction. J Am Coll Cardiol Basic Transl Science. 2021, 01.013.
Wickam H, Tam JCH, Chan XHS, George MJ, Levi M, Brown M. Aortic thrombosis in COVID-19. Clinical Infection in Practice, 2021, 100059.
Jensen MP, George M, Gilroy D, Sofat R. Beyond dexamethasone, emerging immune-thrombotic therapies for COVID-19. Br J Clin Pharmacol, 2020, 14540.
Gupta RK, Marks M, Samuels THA et al on behalf of The UCLH COVID-19 Reporting group. Systemic evaluation and external validation of 22 prognostic models among hospitalised adults with COVID-19. An observational cohort study. Eur Respir J, 2020.
George MJ, Kleveland O, Garcia-Hernandez J, Palmen J, Lovering R, Wiseth R, Aukrust P, Engmann J, Damas JK, Hingorani AD, Gullestad L, Casas JP, Ueland T. Novel insights into the effects of interleukin-6 antagonism in NSETMI employing the SOMAscan proteomics platform. JAHA, 2020;9(12).
George MJ, Marks DJB, Rezk T, Breckenridge R, Sofat R, Martin J, MacAllister R, Touyz RM, Staessen JA, Bursztyn M, Lappin D, Barigou M, Hingorani A. Resistant Hypertension, Trials and Tribulations. Hypertension 2018;71:772-780.
Motwani MP, Bennett F, Norris PC, Maini AA, George MJ, Newson J, Henderson A, Hobbs, AJ, Tepper M, White B, Serhan CN, MacAllister R, Gilroy DW. Potent Anti-Inflammatory and Pro-Resolving Effects of Anabasum in a Human Model of Self-Resolving Acute Inflammation. Clinical Pharmacology and Therapeutics 2018;104(4).
Motwani MP, Colas RA, George MJ, Flint JD, Dalli J, Richard-Loendt A, De Maeyer RPH, Serhan CN, Gilroy DW. Pro-resolving mediators promote resolution in a human skin model of UV-killed Escherichia coli-driven acute inflammation. JCI insight 2018;3(6):e94463.
Parisinos CA, Serghiou S, Katsoulis M, George MJ, Patel R, Hemingway H, Hingorani AD. Variation in Interleukin 6 Receptor Gene Association With Risk of Crohn’s Disease and Ulcerative Colitis. Gastroenterology 2018;155:303-306.
Maini AA*, George MJ*, Motwani MP, Day RM, Gilroy DW, O’Brien AJ. A Comparison of Human Neutrophils Acquired from Four Experimental Models of Inflammation. PLoS ONE 2016; 11(10): e0165502. Doi:10:1371/journal.pone.0165502. *Joint first authors
George MJ, Sofat A, Hingorani A, MacAllister RJ. Diagnosis and Investigation of the Hypertensive Patient. Chapter in Practical Nephrology, Springer, 2014.