Photo of Dr Stefanie Thust

Dr Stefanie Thust

Telephone:

Email:

Location:

  • National Hospital for Neurology and Neurosurgery

GMC/GDC number:

6089508

Professional background

Steffi Thust is a consultant in diagnostic neuroradiology at the National Hospital for Neurology and Neurosurgery and University College Hospital. Steffi has wide-ranging expertise in brain and spine imaging, including advanced MRI and paediatric neuroradiology. She is the Clinical Lead for Neuro-Oncology Imaging and holds a joint research appointment as Honorary Associate Professor with the UCL IoN Department for Brain Rehabilitation and Repair.

Steffi graduated with distinction from the Johannes Gutenberg University Mainz, Germany and obtained an MD magna cum laude. She completed clinical radiology training at Guy’s and St. Thomas’ Hospitals and on the Pan-London Neuroradiology Fellowship programme, with an acting consultant post at Great Ormond Street Hospital for Children.

Steffi’s research topics include the investigation of diffusion-weighted imaging for glioma genotyping, computational methods for tumour characterisation and quantitative imaging of CNS lymphoma. She is co-author of numerous publications, scientific papers and reference works, including the official textbook of the European Society of Neuroradiologists (ESNR).

Her recent roles include membership of the UCL Advanced Neuroimaging MSc committee, the BSNR Academic Subcomittee and UCLH Clinical Effectiveness Steering Group, Lead Consultant for Clinical Governance and Panel Coordinator for the Royal College of Radiologists Fellowship Exams. Steffi is passionate about teaching and recently established a sponsorship programme for international medical graduates at Queen Square.

Specialties

Research interests

Brain tumours, quantitative and advanced MRI methods

Languages spoken

German

Publications

Selected publications

  • Thust SC, Maynard JA, Benenati M, Wastling SJ, Mancini L, Jaunmuktane Z, Brandner S, Jäger HR. Regional and Volumetric Parameters for Diffusion-Weighted WHO Grade II and III Glioma Genotyping: A Method Comparison. AJNR Am J Neuroradiol. 2021 Jan 7. doi: 10.3174/ajnr.A6965.
  • Thust S, Micallef C, Okuchi S, Brandner S, Kumar A, Mankad K, Wastling S, Mancini L, Jäger HR, Shankar. Imaging characteristics of H3 K27M histone-mutant diffuse midline glioma in teenagers and adults. Quant Imaging Med Surg. 2021 Jan;11(1):43-56. doi: 10.21037/qims-19-954.
  • Lasocki A, Anjari M, Ӧrs Kokurcan S, Thust SC. Conventional MRI features of adult diffuse glioma molecular subtypes: a systematic review. Neuroradiology. 2020 Aug 25. doi: 10.1007/s00234-020-02532-7. Online ahead of print. PMID: 32840682
  • Maynard J, Okuchi S, Wastling S, Busaidi AA, Almossawi O, Mbatha W, Brandner S, Jaunmuktane Z, Koc AM, Mancini L, Jäger R, Thust S. World Health Organization Grade II/III Glioma Molecular Status: Prediction by MRI Morphologic Features and Apparent Diffusion Coefficient. Radiology. 2020 Jul;296(1):111-121. doi: 10.1148/radiol.2020191832. Epub 2020 Apr 21.PMID: 32315266
  • Okuchi S, Hammam A, Golay X, Kim M, Thust S. Endogenous chemical exchange saturation transfer imaging for the diagnosis and therapy response assessment of brain tumors: a systematic review. Radiology: Imaging in Cancer 2020. doi.org/10.1148/rycan.2020190036
  • Hyare H, Rice L, Thust S, Nachev P, Jha A, Milic M, Brandner S, Rees J. Modelling MR and clinical features in grade II/III astrocytomas to predict IDH mutation status. Eur J Radiol. 2019 May;114:120-127. doi: 10.1016/j.ejrad.2019.03.003..
  • Okuchi S, Rojas-Garcia A, Ulyte A, Lopez I, Ušinskienė J, Lewis M, Hassanein SM, Sanverdi E, Golay X, Thust S, Panovska-Griffiths J, Bisdas S. Diagnostic accuracy of dynamic contrast-enhanced perfusion MRI in stratifying gliomas: A systematic review and meta-analysis. Cancer Med. 2019 Sep;8(12):5564-5573. doi: 10.1002/cam4.2369. Epub 2019 Aug 7.
  • Kim M, Torrealdea F, Adeleke S, Rega M, Evans V, Beeston T, Soteriou K, Thust S, Kujawa A, Okuchi S, Isaac E, Piga W, Lambert JR, Afaq A, Demetriou E, Choudhary P, Cheung KK, Naik S, Atkinson D, Punwani S, Golay X. Challenges in glucoCEST MR body imaging at 3 Tesla. Quant Imaging Med Surg. 2019 Oct;9(10):1628-1640. doi: 10.21037/qims.2019.10.05.
  • Agn M, Munck Af Rosenschöld P, Puonti O, Lundemann MJ, Mancini L, Papadaki A, Thust S, Ashburner J, Law I, Van Leemput K. A modality-adaptive method for segmenting brain tumors and organs-at-risk in radiation therapy planning. Med Image Anal. 2019 May;54:220-237. doi: 10.1016/j.media.2019.03.005. Epub 2019 Mar 22.
  • Lewis MA, Ganeshan B, Barnes A, Bisdas S, Jaunmuktane Z, Brandner S, Endozo R, Groves A, Thust SC. Filtration-histogram based magnetic resonance texture analysis (MRTA) for glioma IDH and 1p19q genotyping. Eur J Radiol. 2019 Apr;113:116-123. doi: 10.1016/j.ejrad.2019.02.014. Epub 2019 Feb 13.
  • Mansoor NM, Thust S, Militano V, Fraioli F. PET imaging in glioma: techniques and current evidence. Nucl Med Commun. 2018 Dec;39(12):1064-1080.
  • Thust SC, van den Bent MJ, Smits M. Pseudoprogression of brain tumours. J Magn Reson Imaging. 2018 May 7. doi: 10.1002/jmri.26171.
  • Thust SC, Hassanein S, Bisdas S, Rees JH, Hyare H, Maynard JA et al. Apparent diffusion coefficient for molecular subtyping of non-gadolinium-enhancing WHO grade II/III glioma: volumetric segmentation versus two-dimensional region of interest analysis. Eur Radiol 2018 Mar 23. doi: 10.1007/s00330-018-5351-0.
  • Bisdas S, Shen H, Thust S, Katsaros V, Stranjalis G, Boskos C, Brandner S, Zhang J. Texture analysis- and support vector machine-assisted diffusional kurtosis imaging may allow in vivo gliomas grading and IDH-mutation status prediction: a preliminary study. Sci Rep. 2018 Apr 17;8(1):6108. doi: 10.1038/s41598-018-24438-4.
  • Thust SC, Heiland S, Falini A, Jäger HR, Waldman AD, Sundgren PC et al. Glioma imaging in Europe: A survey of 220 centres and recommendations for best clinical practice. Eur Radiol. 2018 Mar 13. doi: 10.1007/s00330-018-5314-5.
  • D'Arco F, O'Hare P, Dashti F, Lassaletta A, Loka T, Tabori U, Talenti G, Thust S et al. Volumetric assessment of tumor size changes in pediatric low-grade gliomas: feasibility and comparison with linear measurements. Neuroradiology. 2018 Apr;60(4):427-436. doi: 10.1007/s00234-018-1979-3.
  • Szychot E, Seunarine K, Mankad K, Thust S, Clark C, Gaze MN, Michalski A. Impact of induction chemotherapy, hyperfractionated accelerated radiotherapy and high-dose thiotepa on brain volume loss and functional status of children with primitive neuroectodermal tumour. Pediatr Blood Cancer. 2017 Nov;64(11). doi: 10.1002/pbc.26619.
  • Hyare H, Thust S, Rees J. Advanced MRI techniques for treatment monitoring of glioma. Curr Opin Neurol. 2017 Mar;19(3):11. doi:10.1007/s11940-017-0445-6. Reivew.
  • Zarkali A, Gorgoraptis N, Miller R, John L, Merve A, Thust S, Jager R, Kullmann D, Swayne O. CD8+ encephalitis: a severe but treatable HIV-related acute encephalopathy. Pract Neurol. 2016 Nov 1.[Epub ahead of print]
  • Thust SC, Yousry T. Imaging of skull base tumours. Pract Oncol Radiother. 2016 Jul-Aug;21(4):304-18. doi: 10.1016/j.rpor.2015.12.008
  • Arenas-Pinto A, Stöhr W, Jäger R, Haddow L, Clarke A, Johnson M, Chen F, Winston A, Godi C, Thust S et al. PIVOT Neurocognitive function and neuroimaging markers and virologically suppressed HIV-positive patients randomized to ritonavir-boosted protease inhibitor monotherpay or standard combination ART: a cross-sectional substudy from the PIVOT trial. Clin Infect Dis. 2016 May 3. pii: ciw279. [Epub ahead of print]
  • Marshall CR, Guerreiro R, Thust S, Fletcher P, Rohrer JD, Fox NC. A novel MAPT mutation causing corticobasal syndrome led by progressive apraxia of speech. J Alzheimers Dis. 2015 Oct 27;48(4):923-6
  • Erro R, Hersheson J, Ganos C, Menacci N, Stamelou M, Batla A, Thust S et al. H-ABC syndrome and DYT4: Variable expressivity or pleiotropy of TUBB4 mutations? Mov Disord. 2014 Dec 27. doi: 10.1002
  • Thust SC, Blanco E, Michalski A, Chong WK, Gaze MN, Phipps K, Mankad K. MRI abnormalities in children following sequential chemotherapy, hyperfractionated accelerated radiotherapy and high-dose thiotepa for high-risk primitive neuroectodermal tumours of the central nervous system. J Med Imaging Radiat Oncol. 2014 Dec;58(6):683-90
  • Thust S, Burke C, Siddiqui A. Neuroimaging findings in sickle cell disease. Br J Radiol 2014; 87(1040):20130699.doi: 10.1259/bjr.20130699.

Book chapters

  • McNamara M, Brandner S, Thust S. Fast Facts: Glioblastoma: New molecular concepts pave the way for advances in diagnosis and treatment. Karger. 2020
  • Thust SC, Micallef C, Jager HR. Imaging of brain tumours. Grainger and Allison’s Diagnostic Radiology 7th edition. 2020
  • Thust SC, Hyare H, Rees JR. Imaging of Treatment Response and Pseudoresponse in Glioblastoma: State-Of-The-Art Neuroimaging. Nova Science Publishers 2019
  • Quirk B, Thust S, Yousry T. Imaging of Low Grade Gliomas in Glioblastoma: State-Of-The-Art Neuroimaging. Nova Science Publishers 2019
  • Thust SC, Kumar A. Extra-axial brain tumours in Clinical Neuroradiology – the ESNR Textbook. Springer 2018
  • Jager HR, Thust SC, Pizzini F. Clinical presentations, differential diagnosis and imaging work-up of cerebral masses in Clinical Neuroradiology – the ESNR Textbook. Springer 2018
  • Kim M, Zaiss M, Thust SC, Golay X. Quantitative Chemical Exchange Saturation Transfer in Quantitative MRI of the Brain: Principles of Physical Measurement, 2nd Edition, Taylor & Francis 2018.
  • Thust S, Miszkiel K, Davagnanam. Imaging of the orbit and visual pathways. Grainger & Allison’s Diagnostic Radiology 6th edition 2013.