Photo of Dr Emma Wall

Dr Emma Wall

Email:

Location:

  • Hospital for Tropical Diseases

GMC/GDC number:

4716754

Professional background

Dr Emma Wall is an academic consultant in Infectious Diseases and Acute Medicine.

She holds a Senior Clinical Research Fellowship, jointly appointed between the Francis Crick Institute and UCLH Biomedical Research Centre. Dr Wall graduated from the University of Bristol in 2000, following UK-based post-graduate training in medicine, she worked in Northern Australia, Uganda and Cambridge prior to higher specialist training in infection and internal medicine in North West London.

Dr Wall did her PhD at the Liverpool School of Tropical Medicine and the Malawi Liverpool Wellcome Trust Clinical Research Programme in Malawi, studying clinical management and epidemiology of bacterial meningitis in Malawian adults. Prior to joining the Francis Crick Institute as a post-doctoral clinical fellow, she was a NIHR clinical lecturer in Infection at UCL.

Specialties

Research interests

Dr Wall the leads the Legacy study, a prospective observational cohort study investigating SARS CoV 2 susceptibility, transmission and disease severity.

Dr Wall is a co-investigator on the STIMULATE-ICP trial investigating management and treatment of Post-COVID syndrome, also known as Long COVID. She has developed a specialist interest in Long COVID, and has been working in the Post-COVID clinic since 2020. She is the lead for the nested drug trial within STIMULATE, Prior to joining the Francis Crick Institute as a post-doctoral clinical fellow, she was a NIHR clinical lecturer in Infection at UCL.

Her primary research interest is invasive infection in clinically vulnerable adults with a particular focus on host-pathogen interactions, neurological infection and improving clinical outcomes from infections caused by Streptococcus pneumoniae. More recently she has focussed on evaluation of humoral and cell-mediated responses to COVID-19 vaccines and mild COVID infection in healthy adults and immunocompromised patient groups within the Legacy and STIMULATE-ICP studies.

Publications

  • Papers in preprint - Mears HV, Young GR, Sanderson T, et al. Emergence of new subgenomic mRNAs in SARS-CoV-2. bioRxiv 2022: 2022.04.20.488895. Under review at Plos Pathogens
  • Townsley H, Carr EJ, Russell TW, et al. Non-hospitalised, vaccinated adults with COVID-19 caused by Omicron BA.1 and BA.2 present with changing symptom profiles compared to those with Delta, despite similar viral kinetics. medRxiv 2022: 2022.07.07.22277367. MS currently being updated to include BA.4/5 infections
  • Wall EC, Guerra-Assunção JA, Pollara G,et al. Cerebrospinal fluid transcriptional analyses reveals both upregulation of IL-17 and Type 1 interferon pathways, and neutrophil persistence genes are associated with increased mortality from pneumococcal meningitis. https://www.biorxiv.org/content/early/2018/12/07/490045 (data under re-analysis post-pandemic)
  • Wall EC, Guerra-Assunção JA, Denis B, Scarborough M, Ajdukiewicz KA, Cartwright K, Venturini C, Mukaka M, Mlozowa VS, Allain TA, Lalloo DG, Gordon SB Brown JS, Heyderman RS. Both the inflammatory response and clinical outcome differ markedly between adults with pneumococcal and meningococcal meningitis in a high HIV-1 prevalent setting in sub-Saharan Africa https://www.biorxiv.org/content/10.1101/539585v1 (data under re-analysis post-pandemic)
  • Fendler A, Shepherd STC, Au L, et al Functional immune responses against SARS-CoV-2 variants of concern after fourth COVID-19 vaccine dose or infection in patients with blood cancer.
  • Cell Reports Medicine (in press) Lim EA, Ruffle JK, Gnanadurai R, Lee H, Escobedo-Cousin M, Wall E, et al.
  • Differentiating central nervous system infection from disease infiltration in hematological malignancy. Sci Rep. 2022 Sep 22;12(1):15805. doi: 10.1038/s41598-022-19769-2.
  • Basset A, Wall E, Mitsi E, et al Targeted Transcriptomic Screen of Pneumococcal Genes Expressed during Murine and Human Infection. Infect Immun. 2022 Jul 21;90(7):e0017522. doi: 10.1128/iai.00175-22
  • Prasannan N, Heightman M, Hillman T, Wall E, et al. Impaired exercise capacity in post-COVID-19 syndrome: the role of VWF-ADAMTS13 axis. Blood Adv. 2022 Jul 12;6(13):4041-4048. doi: 10.1182/bloodadvances.2021006944.
  • Fendler A, Shepherd STC, Au L, et al. Omicron neutralising antibodies after third COVID-19 vaccine dose in patients with cancer. Lancet 2022; 399(10328): 905-7.
  • Wu M, Wall EC, Carr EJ, et al. Three-dose vaccination elicits neutralising antibodies against omicron. Lancet 2022; 399(10326): 715-7.
  • Carr EJ, Wu M, Harvey R, Wall EC, et al. Omicron neutralising antibodies after COVID-19 vaccination in haemodialysis patients. Lancet 2022; 399(10327): 800-2.
  • Fendler A, Shepherd STC, Au L, et al. Adaptive immunity and neutralizing antibodies against SARS-CoV-2 variants of concern following vaccination in patients with cancer: the CAPTURE study. Nature Cancer 2021. https://www.nature.com/articles/s43018-021-00274-w
  • Carr EJ, Wu M, Harvey R, Wall EC et al. Neutralising antibodies after COVID-19 vaccination in UK haemodialysis patients. Lancet 2021; 398(10305): 1038-41.
  • Heightman M, Prashar J, Hillman TE, et al. Post-COVID-19 assessment in a specialist clinical service: a 12-month, single-centre, prospective study in 1325 individuals. BMJ Open Respir Res 2021; 8(1). Nov;8(1):e001041. doi: 10.1136/bmjresp-2021-001041.
  • Fendler, A et al. Immune responses following third COVID-19 vaccination are reduced in patients with hematological malignancies compared to patients with solid cancer. Cancer Cell, Volume 40, Issue 2, 114 - 116
  • Wall EC, Wu M, Harvey R, et al. AZD1222-induced neutralising antibody activity against SARS-CoV-2 Delta VOC. Lancet 2021. ul 17;398(10296):207-209. doi: 10.1016/S0140-6736(21)01462-8
  • Wall EC, Wu M, Harvey R, et al. Neutralising antibody activity against SARS-CoV-2 VOCs B.1.617.2 and B.1.351 by BNT162b2 vaccination. Lancet 2021; 397(10292): 2331-3.
  • van de Beek D, Brouwer MC, Koedel U, Wall EC. Community-acquired bacterial meningitis. The Lancet 2021; 398(10306): 1171-83.
  • Wall EC, Chan JM, Gil E, Heyderman RS. Acute bacterial meningitis. Curr Opin Neurol 2021; 34(3): 386-95.
  • Wall EC, Brownridge P, Laing G, Terra V, et al. CSF Levels of Elongation Factor Tu Is Associated With Increased Mortality in Malawian Adults With Streptococcus pneumoniae Meningitis. Front. Cell. Infect. Microbiol., 11 December 2020 | https://doi.org/10.3389/fcimb.2020.603623
  • Terra VS, Plumptree C, Wall EC, Brown JS, Wren B. Construction of a Pneumolysin Deficient Mutant in Streptococcus Pneumoniae Serotype 1 Strain 519/43 and Phenotypic Characterisation. Microbial Pathogenesis 2020 Apr;141:103999
  • Terra VS, Plumptre CD, Wall EC, Brown JS, Wren BW. Constructing Mutants in Serotype 1 Streptococcus pneumoniae strain 519/43. J Vis Exp 2020; (163).
  • Wall EC, Ajdukiewicz KM, Heyderman RS, Garner P. Osmotic therapies added to antibiotics for acute bacterial meningitis. Cochrane Database Syst Rev 2018;2:CD008806 Wall EC, Mukaka M et al Goal Directed Therapy for suspected bacterial meningitis in adults and adolescents in sub-Saharan Africa. PloS one. 2017;12(10):e0186687.
  • Wall EC, Mukaka M, Scarborough M, Ajdukiewicz KM, et al. Prediction of outcome from adult bacterial meningitis in a high HIV seroprevalence, resource-poor setting using the Malawi Adult Meningitis Score (MAMS). Clinical Infectious Diseases 2017;64(4):413-9. Publication gap 2015-7 for completion of PhD, maternity leave and return to clinical training
  • Wall EC, Everett DB, Mukaka M, Bar-Zeev N, Feasey N, et al. Bacterial meningitis in Malawian adults, adolescents, and children during the era of antiretroviral scale-up and Haemophilus influenzae type b vaccination, 2000-2012. Clinical Infectious Diseases 2014;58(10): e137-45.
  • Wall EC, Gritzfeld JF, Scarborough M, Ajdukiewicz KM, Mukaka M, et al. Genomic pneumococcal load and CSF cytokines are not related to outcome in Malawian adults with meningitis. The Journal of Infection 2014; 69(5): 440-6.
  • Wall EC, Cartwright K, Scarborough M, Ajdukiewicz KM, et al. High Mortality amongst Adolescents and Adults with Bacterial Meningitis in Sub-Saharan Africa: An Analysis of 715 Cases from Malawi. PloS one 2013; 8(7): e69783.
  • Wall EC, Ajdukiewicz KM, Heyderman RS, Garner P. Osmotic therapies added to antibiotics for acute bacterial meningitis. Cochrane Database Syst Rev 2013; 3: CD008806.
  • Wall EC, Gordon SB, Hussain S, Goonetilleke UR, Gritzfeld J, Scarborough M, Kadioglu A. Persistence of pneumolysin in the cerebrospinal fluid of patients with pneumococcal meningitis is associated with mortality. Clinical Infectious Diseases : 2012; 54(5): 701-5.
  • Okoromah CA, Afolabi BB, Wall EC. Mannitol and other osmotic diuretics as adjuncts for treating cerebral malaria. Cochrane Database Syst Rev 2011; (4): CD004615. Wall EC, Watson J, Armstrong M, Chiodini PL, Lockwood DN. Epidemiology of imported cutaneous leishmaniasis at the Hospital for Tropical Diseases, London, United Kingdom: use of polymerase chain reaction to identify the species. The American Journal of Tropical medicine and hygiene 2012; 86(1): 115-8.
  • Wall EC, Bhatnagar N, Watson J, Doherty T. An unusual case of hypereosinophilia and abdominal pain: an outbreak of Trichostrongylus imported from New Zealand. Journal of Travel Medicine 2011; 18(1): 59-60.
  • Herman JS, Wall EC, van-Tulleken C, et al. Gnathostomiasis acquired by British tourists in Botswana. Emerging Infectious Diseases 2009; 15(4): 594-7.
  • Macfie C, Wall E, Ash S. Paracetamol overdose presenting with hyperglycaemia, acidosis and ketonuria in a non-diabetic patient. Acute Medicine 2009; 8(2): 78-9.
  • Wall EC, Ghazy A, Bulley S, Ahmad F, Aali A, Lynn W. Medical staff at a London district hospital are not chronic vectors of MRSA or Clostridium difficile. Journal of Infection 2009; 58(6): 469-71.
  • Longley N, Muzoora C, Taseera K, Mwesigye J, Rwebembera J, Chakera A, Wall E, Andia I, Jaffar S, Harrison TS. Dose response effect of high-dose fluconazole for HIV-associated cryptococcal meningitis in southwestern Uganda. Clinical Infectious Diseases 2008; 47(12): 1556-61.
  • Haydock SF, Bornshin S, Wall EC, Connick RM. Admissions to a U.K. teaching hospital with nonnecrotizing lower limb cellulitis show a marked seasonal variation.
  • Br J Dermatol 2007; 157(5): 1047-8. 
  • Wall EC. Manson’s Clinical Cases in Tropical Medicine, Ed Camilla Rothe. Elsevier Publications 2014, 2019
  • Wall EC, Cooke G. Fever Ch Infections. Oxford Diagnosis and Treatment in Internal Medicine; Ed Davey P, and Sprigings D. Oxford University Press 2018
  • Wall EC, Chiodini PL. Vector Borne parasitic diseases. Textbook of Travel Medicine Ed J Zuckermann. 2010
  • Wall EC, Cooke G. Jaundice in travellers. Medicine 2010 Jan;38(1):14-17