Dr Elaine Borg

Recent publications

Bentham R, et al, TRACERx Consortium, Swanton C, McGranahan N. Using DNA sequencing data to quantify T cell fraction and therapy response. Nature Res 2021 Sep 597(7877):1-6 DOI: 10.1038/s41586-021-03894-5

Venkatesan S, et al (TRACERx Consortium⁾. Induction of APOBEC3 Exacerbates DNA replication Stress and Chromosomal Instability in Early Breast and Lung Cancer Evolution. Cancer Discov Oct 2021;11:2456–73. doi: 10.1158/2159-8290.CD-20-0725

Lewis Au et al; Renal TRACERx Consortium. Determinants of anti-PD-1 response and resistance in clear cell renal cell carcinoma. Cancer Cell 2021 Nov. 39, 1497–1518. https://doi.org/10.1016/j.ccell.2021.10.001

Ishii Y, Kolluri K, Pennycuick A, Zhang X, Nigro E, Alrifai D, Borg E, Falzon M, Shah K, Kumar N, Janes S. BAP1 and YY1 regulate expression of death receptors in malignant pleural mesothelioma. J Biol Chem. 2021 Nov;297(5):101223. doi: 10.1016/j.jbc.2021.101223. Epub 2021 Sep 29.

Litchfield K, et al; PEACE Consortium, Larkin J, Swanton C, Alexander NR, Turajlic S. Cell Rep. 2020 May Representative Sequencing: Unbiased Sampling of Solid Tumor Tissue. 5;31(5):107550. doi: 10.1016/j.celrep.2020.107550.

AbdulJabbar K, et al; TRACERx Consortium, Swanton C, Yuan Y. Nat Med. Geospatial immune variability illuminates differential evolution of lung adenocarcinoma. 2020 Jul;26(7):1054-1062. doi: 10.1038/s41591-020-0900-x. Epub 2020 May 27. PMID: 32461698

López S, et al; TRACERx Consortium, Swanton C, McGranahan N. Interplay between whole-genome doubling and the accumulation of deleterious alterations in cancer evolution. Nat Genet. 2020 Mar;52(3):283-293. doi: 10.1038/s41588-020-0584-7.

Joshi K, et al; TRACERx consortium, Quezada SA, Spatial heterogeneity of the T cell receptor repertoire reflects the mutational landscape in lung cancer. Chain B. Nat Med.2019 Oct;25(10):1549-1559. doi: 10.1038/s41591-019-0592-2.

Biswas D, et al; TRACERx Consortium. A clonal expression biomarker associates with lung cancer mortality. Nat Med. 2019 Oct;25(10):1540-1548. doi: 10.1038/s41591-019-0595-z.

Chemi F, et al; TRACERx Consortium. Pulmonary venous circulating tumour cell dissemination before tumour resection and disease relapse. Nat Med. 2019 Oct;25(10):1534-1539. doi: 10.1038/s41591-019-0593-1.

Rosenthal R, et al; TRACERx consortium. Neoantigen-directed immune escape in lung cancer evolution. Nature. 2019 Mar;567(7749):479-485. doi: 10.1038/s41586-019-1032-7.

Perrotta F, Khiroya R, Russell P, Ekeowa U, Saleem A, Borg E, Ahmad T, Falzon M, Forster M, Navani N. Diagnosis of Combined Adenocarcinoma Small Cell Lung Cancer By Endobronchial Ultrasound Transbronchial Needle Aspiration. J Bronchology Interv Pulmonol. 2019 Apr;26(2):e20-e22. doi: 10.1097/LBR.0000000000000573.

Kumar N, Alrifai D, Kolluri K, Sage E, Ishii Y, Guppy N, Borg E, Falzon M, Nankivell M, Nicholson A, Janes S. Retrospective response analysis of BAP1 expression to predict the clinical activity of systemic cytotoxic chemotherapy in mesothelioma. Lung Canc.2019 Jan;127:164-166. doi: 10.1016/j.lungcan.2018.12.004. Epub 2018 Dec 5.

Vargas F, et al; TRACERx Melanoma; TRACERx Renal; TRACERx Lung consortia, Pule M, Marafioti T, Gore M, Larkin J, Turajlic S, Swanton C, Peggs KS, Quezada SA. Fc Effector Function Contributes to the Activity of Human Anti-CTLA-4 Antibodies. Cancer Cell. 2018 Apr 9;33(4):649-663

Vargas F et al; TRACERx Melanoma; =TRACERx Renal; TRACERx Lung consortia, Turajlic S, Gore M, Larkin J, Swanton C, Chester K, Pule M, Ravetch J, Marafioti T, Peggs KS, Quezada SA.Fc-Optimized Anti-CD25 Depletes Tumor-Infiltrating Regulatory T Cells and Synergizes with PD-1 Blockade to Eradicate Established Tumors. Immunity 2017 Apr 18;46(4):577-586. doi: 10.1016/j.immuni.2017.03.013. Epub 2017 Apr 11.

Sinharay R, Mithra S, Patel P, Ah-Moye A, Morrow S, Khiroya R, Falzon M, Borg E, Ahmed T, Forster M, Navani N. EGFR mutation specific immunohistochemistry revolutionises time to treatment with tyrosine kinase inhibitors (TKIs). Lung Cancer. 2018. 115. 115:S24

Kumar N, Kolluri K, Sage E, Borg E, Falzon M, Nicholson A, Janes S. BAP1 expression and treatment outcomes in malignant mesothelioma. European Respiratory Journal 2017 50: OA298; doi: 10.1183/1393003.congress-2017.OA298

Kumar N, Kolluri K, Rifai DA, Ishii Y, Borg E, Falzon M, Nicholson A, Janes S. S22 Bap1 expression and treatment outcomes in malignant pleural mesothelioma in a prospective UK based clinical trial. Thorax 2017;72:A16-A17.

Patrini D, Scolamiero L, Khiroya R, Lawrence D, Borg E, Hayward M, Panagiotopoulos N. Mediastinal hemangioendothelioma: Case report and review of the literature. Respir Med Case Rep. 2017 Jun 3;22:19-23.

McGranahan N et al; TRACERx Consortium. Allele-Specific HLA loss and Immune Escape in Lung Cancer Evolution. Cell. 2017 Nov 30;171(6):1259-1271.e11. doi: 10.1016/j.cell.2017.10.001. Epub 2017 Oct 26.

Thakrar R, Pennycuick A, Borg E, Janes S. Preinvasive disease of the airway. Cancer Treatment Reviews .Jul 2017.58:77-90. doi:10.1016/j.ctrv.2017.05.009

Stamatopoulos A, Patrini D, Mitsos S, Khiroya R, Borg E, Hayward M, Lawrence D, Panagiotopoulos N. An unusual late onset of pulmonary alveolar microlithiasis: A case report and literature review. Respir Med Case Rep. 2017 May 31;22:24-27.

Jamal Al-Hanjani M, et al (TRACERx Consortium⁾ Tracking the Evolution of Non–Small-Cell Lung Cancer. The New England Journal of Medicine, April 2017 DOI: 10.1056/NEJMoa1616288

Abbosh C, et al (TRACERx and PEACE Consortium) Phylogenetic ctDNA analysis depicts early stage lung cancer evolution. Nature, April 2017 doi:10.1038/nature22364

Barret A, Da Silva S, Kolluri K, Carroll B, Falzon M, Borg E, George J, Janes S, Teixeira V. MA12.02 MMP12 and

LMO7, Two Key Players on opposite Sides of Early Lung Squamous Cell Carcinoma Development. DOI: 10.1016/j.jtho.2016.11.471. 2017.

Barret A, Lourenco S, Kolluri K, Carroll B, Falzon M, Borg E, George J, Janes S, Teixeira V. S6 MMP12 and LMO7, two key players on opposite sides of early lung squamous cell carcinoma development. Thorax 71(Suppl 3):A6.2-A6. 2016

Conti C, Montero A, Borg E, Osadolor T, Viola P, De lauretis A, Stock C, Bonifazi M, Bonini M, Caramori G, Lindahl G, Blasi F, Nicholson AG, Wells A, Sestini P, Renzoni E. Mucins MUC5B and MUC5AC in Distal Airways and Honeycomb Spaces: Comparison among Idiopathic Pulmonary Fibrosis/Usual Interstitial Pneumonia, Fibrotic Nonspecific Interstitial Pneumonitis, and Control Lungs. American Journal of Respiratory and Critical Care Medicine 193(4):462-464 · 2016. DOI: 10.1164/rccm.201507-1322LE

Stamatopoulos A, Patrini D, Koletsis E, Borg E, Khiroya R, Hayward M, Lawrence D, Panagiotopoulos N. IgG4 related lung disease extending to the thoracic vertebrae. Respiratory Medicine Case Reports 19. 2016

Patrini D, Shukla R, Lawrence D, Borg E, Hayward M, Panagiotopoulos N. Sclerosing haemangioma of the lung showing strong FDG avidity on PET scan: Case report and review of the current literature. Respiratory Medicine Case Reports (17) 20-23. 2016

Mikolasch TA, Borg E, Thakrar R, Holmes V, Booth HL, Porter H, Navani N. S42 Transbronchial cryobiopsies in the diagnosis of Interstitial Lung Diseases- first UK experience. Thorax 70(Suppl 3):A27.3-A28. 2015. doi: 10.1136/thoraxjnl-2015-207770.48

Panagiotopoulos N, Patrini D, Gvinianidze L, Woo WL, Borg E, Lawrence D. Inflammatory myofibroblastic tumour of the lung: A reactive lesion or a true neoplasm? Journal of Thoracic Disease 7(5):908-11. 2015

Pararajasingham J, Lawrence D, Patrini D, Gulamhussein MA, Borg E, Panagiotopoulos N. A case of biphasic pulmonary blastoma presenting in a 55 year old man. Case reports in Clinical Pathology, Vol.2, No. 3. 2015

Shukla R, Patrini D, Borg E, Lawrence D, Hayward M, Panagiotopoulos N. The potential malignancy of a solitary fibrous tumour of the lung. Case reports in Clinical Pathology, Art. ID209490. 2015

Thakar RM, Hardavella G, Janes SM, Succony L, Falzon M, Borg E, Jeebun V, Munnavar M, Navani N. P220 Role of EBUS -TBNA in the diagnosis of Primary and Relapsing Haematological Malignancy. Thorax 69 (Suppl2):A174-A174. 2014.

Woo WL, Panagiotopoulos N, Gvinianidze L, Fhadil S, Borg E, Falzon M, Lawrence D. Primary Synovial Sarcoma of the Lung: Can haemothorax be the first manifestation?. Journal of Thoracic Disease 6(12):E249-51. 2014.

Gvinianidze L, Panagiotopoulos N, Woo WL, Borg E, Lawrence D. The challenging management of lung choriocarcinoma. Journal of Thoracic Disease 6(10):E220-222. 2014.

Gerada J, Borg E, Cassar M, DeGaetano J, Laferla G. Crohn’s disease manifesting as an isolated caecal polyp and secondary appendiceal obstruction. Int J Colorectal Dis.; 29(10):1307-1308. 2014

Gerada J, Borg E, DeGaetano J, Pocock K. Gastric giant folds in a patient with hypoalbuminaemia. BMJ Case Reports; doi:10.1136/bcr-2012-008284. 2014

Torpiano P, Borg E, Cassar P, Manche A. Intrathoracic Schwannoma with Horner’s Syndrome. BMJ Case Reports; doi:10.1136/bcr-2013-201247. 2013