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Publish date: 22 May 2020
UCLH is to trial the COVID-19 vaccine developed by University of Oxford in healthy staff volunteers.
Recruitment will focus on healthcare workers who have had a higher chance of exposure to the SARS-CoV-2 virus. This includes, for example, clinical staff in intensive care, A&E and COVID-19 wards, as well as non-clinical staff working in COVID-19 wards such as hospital porters and cleaners.
Screening for the trial at UCLH is due to begin next week, and researchers plan to begin vaccinations in 500 volunteers in June.
Professor Vincenzo Libri, Director of the National Institute for Health Research UCLH Clinical Research Facility, will lead the study at UCLH. The NIHR UCLH/UCL Biomedical Research Centre is supporting delivery of the trial, which was set up by the UCLH/UCL Joint Research Office.
Participants will be randomised to receive one or two doses of either the ChAdOx1 nCoV-19 vaccine developed by Oxford or a licensed vaccine (MenACWY) that will be used as a ‘control’ for comparison.
The study will assess if healthy people can be protected from COVID-19 with this new vaccine, and provide valuable information on safety aspects of the vaccine and its ability to generate good immune responses against the virus.
At regular intervals after vaccination researchers will carry out blood tests and collect information about any symptoms that occur. Biological samples will be analysed at the Francis Crick Institute and Health Services Laboratories.
Professor Libri said: “We are excited to begin our portion of this trial at UCLH as we urgently need a vaccine – both to combat the current pandemic and to prevent future outbreaks. We hope we are able to demonstrate that this vaccine can protect against the coronavirus. I want to say a huge thank you to the incredible taskforce whose exemplary dedication has allowed the set-up of this study at record speed.”
UCLH Chief Executive Professor Marcel Levi said: “I am proud that we at UCLH are involved in this study and I thank all colleagues who are contributing to our efforts – either by running the trial or by taking part in it.”
UCLH Director of Research Professor Bryan Williams said: “Our Biomedical Research Centre is coordinating over 40 important studies of Covid-19 at UCLH but the development of an effective vaccine is a key study as it offers the best hope of beating this disease and we are delighted to be contributing to this hugely important national effort.”
The first phase of the nationwide trial in adult volunteers began in Oxford in April. So far more than 1,000 immunisations have been completed, and follow up is ongoing.
In this ‘phase III’ trial, up to 10,260 adults and children will be recruited at research centres across the UK, to see how the vaccine works in a larger number of people.
